3 edition of Apoptosis, genomic integrity, and cancer found in the catalog.
Apoptosis, genomic integrity, and cancer
Julien L. Van Lancker
|Statement||Julien L. Van Lancker.|
|The Physical Object|
|Pagination||xviii, 422 p. :|
|Number of Pages||422|
Evasion of apoptosis may be a question of balance. Damage to DNA can render a cell useless, or even harmful to an organism. Apoptosis, or programmed cell death, evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells. 1 A hallmark of cancer is the ability of malignant cells to evade apoptosis. 2 Cancer cells exhibit many characteristics that would . This entry was posted in Apoptosis, Growth Receptors, Signal Transduction, Traditional Chemotherapy, Uncategorized and tagged 5-FU, Amgen, apoptosis, Colon cancer, EGFR, FOLFOX, leucovorin, oxaliplatin, panitumumab, Ras, Vectibix on J by Joseph Gulfo. What do pineapples, glucose, and cancer have in common – mitochondria.
This is a remarkable property because the demonstration of apoptosis in MCF-7 breast cancer cells by known apoptosis-inducing agents has proved to be difficult and only few cytotoxic agents act preferentially through an apoptotic mechanism in human breast cancer cells [,]. Finally, a fact worth emphasizing is that 7e (the only compound Cited by: 3. Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by the Cited by:
One category of germline apoptosis, dubbed “physiological” germline apoptosis, reduces the number of cells that complete oogenesis, and is independent of the BH3-only apoptosis effecter EGL A second category, termed “stress-induced” germline apoptosis, is triggered by a genomic integrity checkpoint. Apoptosis in Normal Development and Cancer - CRC Press Book In apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die.
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Get this from a library. Apoptosis, genomic integrity, and cancer. [Julien L Van Lancker] -- Harmonious survival of the entire organism depends on the rigorous preservation of the controls that regulate the balance between the cell's replication and. Apoptosis, Genomic Integrity and Cancer selected product title First Edition Julien L.
Van Apoptosis, MD. Van Lancker’s book introduces readers to the molecules involved in apoptosis and genomic integrity and considers the gain or loss of the functions that lead to cancer.
This excellent educational resource is designed for scientists and. Van Lancker’s book introduces readers to the molecules involved in apoptosis and genomic integrity and considers the gain or loss of the functions that lead to cancer.
Harmonious survival of the entire organism depends on the rigorous preservation of the controls that regulate the balance between the cell’s replication and apoptosis.
Please wait a moment while we find what you are looking for. Author/creator: Van Lancker, Julien L., Format: Book and Print: Publication Info: Sudbury, MA: Jones and Bartlett Publishers, © Description.
Biochemical changes in apoptosis. Broadly, three main types of biochemical changes can be observed in apoptosis: 1) activation of caspases, 2) DNA and protein breakdown and 3) membrane changes and recognition by phagocytic cells .Early in and cancer book, there is expression of phosphatidylserine (PS) in the outer layers of the cell membrane, which has Cited by: focus on the complex interplay between genomic (in)stability and apoptosis regulation (BOX 2) that partic-ipates in carcinogenesis.
The relationship between genomic integrity and cell-death regulation can follow at least three different non-exclusive patterns,all of which might be important for the development of ,genomic instabilityCited by: Autophagy and genomic integrity.
and the importance of this crosstalk in cancer and neurodegeneration will be presented in an integrated fashion. At last, we present a. Maintenance of genomic integrity and the development of cancer; Dialogue replaces monologue: heterotypic interactions and the biology of angiogenesis; Moving out: invasion and metastasis; Crowd control: tumor immunology and immunotherapy; The rational treatment of cancer.
P53 and apoptosis: master guardian, and executioner; Description 1 v. The research program in the Laboratory of Genome Integrity is focused on the exploration of the causes and effects of genomic instability, mechanisms of DNA repair and the study of DNA repair breakdown as an initiating or protective event in aging and cancers.
Apoptosis is the programmed cell death which maintains the healthy survival/death balance in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases.
The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis.
The apoptotic Cited by: Autophagy, a lysosome-dependent degradation pathway that is activated by stressful situations such as starvation and oxidative stress, regulates cell fate after DNA damage and also has a pivotal role in the maintenance of nuclear and mitochondrial genomic by: Genomes are continually subjected to DNA damage whether they are induced from intrinsic physiological processes or extrinsic agents.
Double-stranded breaks (DSBs) are the most injurious type of DNA damage, being induced by ionizing radiation (IR) and cytotoxic agents used in cancer treatment.
The failure to repair DSBs can result in aberrant chromosomal Author: Augusto Nogueira, Mara Fernandes, Raquel Catarino, Rui Medeiros. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists.
An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much Cited by: A big challenge for a successful colon cancer treatment is the lack of eradication of the entire tumour cell population and consequent development of chemoresistance.
Control of cell number from tissues and elimination of cells predisposed to malignant transformation, having an aberrant cell cycle or presenting DNA mutations, might be performed by a cellular ‘suicide’ mechanism Cited by: 1. The inactivation of programmed cell death, or apoptosis, is central to the development of cancer.
This disabling of apoptotic responses might be a major contributor both to treatment resistance. Genomic Integrity of Mouse Embryonic Stem Cells diffusible hydrogen peroxide (H 2 O 2) are inducing base oxidation (Marnett, ).
Challenging. Telomeric DNA plays a role in directing the cell into senescence, or into the pathways of apoptosis, proliferation, immortalization, and cancer. They also have a role in DNA repair; telomeric repeats are often inserted during the repair of double strand breaks. The maintenance of genomic stability involves telomere integrity.
As such, Apoptosis and Cancer describes the performance of contemporary techniques for studying the biology of apoptosis and its role in cancer. This book is a collaboration between academics- and industry-based scientists. The chapters have the technical development characteristic of an academic environment and the standardized system.
Apoptosis (from Ancient Greek ἀπόπτωσις, apóptōsis, "falling off") is a form of programmed cell death that occurs in multicellular organisms.
Biochemical events lead to characteristic cell changes and changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global [vague] mRNA : D.
DNA-repair pathways, such as base excision repair, nucleotide excision repair, mismatch repair, nonhomologous end joining, and homology-directed repair, play a critical role in maintaining genomic integrity.
A deficiency of these pathways may therefore lead to genomic instability which is a hallmark of almost all types of human malignancies.The biology and genetics of cells and organisms --The nature of cancer --Tumor viruses --Cellular oncogenes --Growth factors and their receptors --Cytoplasmic signaling circuitry programs many of the traits of cancer --Tumor suppressor genes --pRb and control of the cell cycle clock --p53 and apoptosis: master guardian and executioner --Eternal.Mol Cancer Ther St.
John JC et al. () The analysis of mitochondria and mitochondrial DNA in human embryonic stem s Mol Biol– Genomic DNA Fragmentation: TUNEL Assay. Another hallmark of apoptosis .